Peptonedesignssmallmoleculesagainstintrinsicallydisorderedproteins,theshape-shiftingdriversofdiseasethatconventionaldrugscan'treach.

A clinician holding the hand of a cancer patient receiving chemotherapy through an IV

Mission

We read the physics of disordered proteins, model it with AI, and design medicines that change what a cancer diagnosis can mean.

Peptone is building a generational company in a category of its own making: precision-guided therapeutics for the shape-shifting proteins behind solid tumors, and the diseases beyond them. We measure our progress first by the potential of our pipeline, and ultimately by the number of patients we can treat.

Science

Peptone is building a new way to drug proteins that do not settle into one stable shape.

Measuring a transient pocket on a disordered chainA breathing disordered protein chain with a fleeting cavity framed by a targeting reticle, a dimension line, and HDX uptake dots.
Measuretheir transient pockets
Modelling the moving ensemble of conformersThe same chain drawn as a superposition of morphing conformers over a faint density stipple.
Modeltheir moving ensembles
A designed binder cradled inside an induced alpha-helixA small-molecule binder held inside an ordered alpha-helix with a travelling sheen and frayed disordered termini.
Designbinders against disease-driving disorder

Measuring the moving target

HDX-MS, GPU-accelerated ensemble modeling, and generative AI form a closed loop for finding binders against invisible pockets.

Disordered protein in motionAn abstract backbone continuously folds and unfolds between conformations, evoking the movement of an intrinsically disordered protein ensemble.

Drugging invisible pockets

Peptone combines structural biology, computation, and translational assays so disorder becomes a tractable therapeutic surface.

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