Peptonedesignssmallmoleculesagainstintrinsicallydisorderedproteins,theshape-shiftingdriversofdiseasethatconventionaldrugscan'treach.

We read the physics of disordered proteins, model it with AI, and design medicines that change what a cancer diagnosis can mean.
Peptone is building a generational company in a category of its own making: precision-guided therapeutics for the shape-shifting proteins behind solid tumors, and the diseases beyond them. We measure our progress first by the potential of our pipeline, and ultimately by the number of patients we can treat.
Peptone is building a new way to drug proteins that do not settle into one stable shape.
HDX-MS, GPU-accelerated ensemble modeling, and generative AI form a closed loop for finding binders against invisible pockets.
Peptone combines structural biology, computation, and translational assays so disorder becomes a tractable therapeutic surface.